![]() ![]() A 13 mm (out of 100) difference was considered clinically significant. The primary outcome was relief of pain (as measured by the difference in millimeters between the pretreatment and posttreatment visual analog scales) at 30 minutes. Group 3: 30 mL of Mylanta plus 10mL of Donnatal plus 10 mL of 2% viscous lidocaine Outcome Group 2: 30 mL of Mylanta plus 10mL of Donnatal (a combination of phenobarbital, hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide, meant to act as an antispasmodic and anticholinergic agent) Group 1: 30 mL of Mylanta (a combination of magnesium hydroxide, aluminium hydroxide, and simethicone) Exclusions: Suspected cardiac or pulmonary etiology (including patients receiving any cardiovascular medications in the ED), pregnancy, oral warfarin therapy, active GI bleeding (other than heme-positive stool), incompetence to consent, and self-administration of antacid within 1 h.PatientsĪ convenience sample of adult patients with dyspepsia for whom the emergency doctor ordered a “GI cocktail”. This is a single centre, double-blind, randomized controlled trial. The GI Cocktail is no more effective than plain liquid antacid: a randomized, double blind clinical trial. The patients only had “possible” MI, and we are given no further details.) However, the primary question for this post is: does a pink lady provide any more pain relief than an antacid alone? The paperīerman DA, Porter RS, Graber M. I started looking, and the only citation I could find was Wrenn 1995, in which they say “eight (73%) of eleven patients admitted for possible myocardial ischemia were noted to have some degree of relief after the GI cocktail.” (Wrenn 1995) That is far from definitive. (As an aside, please let me know if you are aware of the studies that led to the common teaching that the pink lady leads to misdiagnosis in the setting of ACS. Others warn against it, for fear that it can lead to misdiagnosis in the setting of MI. Some practitioners use it as a matter of routine. This prospective open-label study in a large number of pregnant women has shown that LG is both safe and highly efficacious in the treatment of heartburn and GER symptoms in pregnancy.The “pink lady” or “GI cocktail”, a combination of an antacid and viscous lidocaine, is both much loved and much hated in emergency medicine. Very few adverse events or serious adverse events were reported that were considered to be related to the study medication, and these were consistent with the normal population incidences. Treatment was deemed to be a success in 91% of patients as judged by the investigator (95% CI 85.0-95.3) and 90% (95% CI 84.1-94.8) when assessed by the patient themselves. The efficacy of the study medication was rated by the investigator (primary endpoint) and patient. The study was a multicentre, prospective, open-label, and baseline-controlled study of Liquid Gaviscon (LG) in the treatment of heartburn in pregnant women with current symptoms of heartburn and/or reflux requiring treatment (recruited 144). Here, we present a prospective clinical evaluation of the safety and efficacy of an alginate raft-forming oral suspension that is licensed for use in pregnancy. These symptoms are transient and mostly resolve postpartum but have a negative impact on quality of life. Gastro-oesophageal reflux (GER) and the symptoms of heartburn and regurgitation are common in pregnancy.
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